Mark Simon's journey into cancer research began in 2004, building on nearly four decades of study in plant-based nutrition, holistic health, and natural medicine that started in 1982. Motivated by a deep conviction that effective, nontoxic alternatives to surgery, radiation, and chemotherapy exist through nutritional intervention and natural agents, Mark founded NORI — the Nutritional Oncology Research Institute — in 2011. Under his leadership, NORI has grown from an independent research organization into a globally accessible cancer support program serving patients with breast, prostate, thyroid, and advanced cancers. Mark personally developed the NORI Protocol, which leverages cycled methionine restriction and proprietary nutraceutical combinations to target universal cancer cell vulnerabilities. He continues to guide patients worldwide and lead ongoing research into nutritional cancer prevention.